Aamna Sharif finished her schooling from St. Anne’s High School in Mumbai and while she was pursuing graduation, she also did some modelling assignments. She started off her professional career as a model. She during her modelling days appeared in commercials of brands like Beetel Mobile Phones, Close-Ip Toothpaste, Nescafe, Clearasil Skin Cream and Emami Cosmetic Cream. She also appeared in some famous music videos such as Yeh Kisne Jaadu Kiya by Falguni Pathak and Chalne Lagi Hain Hawayein from Abhijeet Bhattacharya among many others.
After a successful career in modelling, she made her acting debut with the famous series, Kahiin Toh Hoga in 2003. She became an instant hit among the viewers. Her beautiful smile, innocent looks, and chemistry with her co-star Rajeev Khandelwal made her a household name in India. After this series, she started getting offers from Bollywood and she made her film debut with a romantic comedy film titled Aloo Chaat in 2009. After which she appeared in few more Bollywood film but was never able to establish herself as a leading actress in Bollywood.
She after a long layoff from the small screen again returned to the small screen in 2012 with the serial called Honge Juda Na Hum. She played the title role and for her performance, she won the Favourite Comeback Award. However, since the ratings started going down the show came to an end in 2013.