Biju Menon began his acting career with Malayalam Television shows such as Parudeesayilekulla Patha, Mikhayelinte Santhathikal and Ningalude Swantham Chanthu. He made his debut in films with Puthran. He acted in a string of movies as Villain and as a supporting Actor. During late 1990s, he was regarded to be the superstar in making. But most of his films as lead hero failed to make an impact at the box office, albeit of his good performance, but his roles as supporting were immensely popular.
He is regarded as the foremost choice of noted Director Lal Jose, as he has starred in the large number of movies directed by him, including Chandranudikkunna Dikhil, Oru Maravathoor Kanavu, Rasikan, Chanthupottu, Randaam Bhavam,Pattalam, Spanish Masala and Mulla. He also acted as an antagonist in Tamil films and his movies like like Thambi and Majaa were very successful.
He married the famous Malayalam actress Samyuktha Varma, who was also his co-star. The couple is blessed with a son, Daksh Dharmik.