Lowe's began her career at the age of two by appearing in a Curiosity Killed the Cat music video. After a photo shoot for Teen Vogue, Lowe was dappled by a talent scout in Camden while she was fifteen and was immediately contracted by Select Model Management. Her breakthrough moment of modeling career came in 2006 when she was photographed by Stephen Klein for Italian Vogue. After establishing herself as a sought out model she posed nude for the cover of Playboy in 2011.
Lowe has been the face of several fashion campaigns which includes Agent Provocateur and Marc by Marc Jacobs. She has walked the ramp to promote Chanel, Burberry, and Vivienne Westwood shows.
In addition to modeling, Daisy has also featured in various music videos like Dirty Pretty Things single Bloodthirsty Bastards, Armand Van Helden’s single NYC Beat, and Sam Smith's single Leave Your Lover. She has also acted in films like Confine and Pressure amongst others.