Isha began playing Tennis from the age of 7. Isha first came to limelight in the year 1999 by making it to the semifinals of the Under 14 and Under 16 championship. In the Under - 14 championships, she defeated Karnataka's wonder girl Iciri Rai with a score line of 6-3 6-3 while in the Under-16, Lakhani defeated Delhi's Ankita Bhambri 5-7 6-1 6-4.
The next success step of her sporting life was at Asian junior tennis championship 2003. It was Saturday of December 13 when she went on to win the title at D L T A Complex New Delhi. A few people doubted her success because of withdrawal of top seeded Yung-Jan Chan due to complaining of a back-ache but it must be kept in mind that at that moment Isha Lakhani was leading with 6-4, 3-0.
She also represented India NEC World Youth Cup in Jakarta May2000,National Championship 2001. She has the talent to meet with the future challenges. All the Tennis experts were looking at her as the next Indian woman tennis sensation, after the Sania Mirza. She did well till she was playing but in recent years she has been hardly seen on court.