She enrolled at the Indiana University and UCLA to study theatre but she dropped out before completing her graduation. She made her television debut as Chelsea Reardon in the series titled Guiding Light. She played this role for 5 long years from 1986 to 1991. She simultaneously made her silver screen debut with the film Evil Dead II in which she played the role of Bobby Joe.
In addition to acting, she was also seen hosting when she hosted the show named The Pro Shop. She appeared in a string of television shows with a guest role in shows like Melrose Place, Time Trax, General Hospital and Baywatch.
In 2014, Soap Opera Digest signed DePaiva for the NBC series Days of Our Lives in the role of Eve Donovan. DePaiva made her debut on the show on 18th July 2014. De Paiva was allowed to leave the show and she made her last her last appearance in early 2016.
She was last seen in the guest role in the series titled Castle in 2016.