Nandamuri Kalyan Ram was born in an illustrious family which consisted of actors and politicians. He too decided to build a career in acting. He started his cinematic journey as a child artist with the Telugu film Bala Gopaludu in 1989. He made his full fledge acting debut with the film titled Toli Choopulone in 2003. His next release was Abhimanyu. His first two releases failed miserably at the box-office.
He gave the first hit of his career in Athanokkade. In addition to acting, he was also the producer of the film.The film was also remade in Tamil and was dubbed in Hindi as well. The success of Athanokkade was followed by the even bigger hit in Hare Ram in which he played the dual role. He then started producing all his films. He took a break from acting in 2010 and returned after three years in India's first 3D Action film titled Om 3D. His 2015 released film Pataas is the biggest hit film of his acting career. His production house is named ‘NTR Arts’.
Recently, he produced a film with his half brother Jr. NTR in the lead role titled Jai Lava Kusa. As an actor and producer, he is one of the most sought after celebrity of Telugu film industry.