Paresh Ganatra attended Lions Juhu High School, Mumbai. He pursued his graduation from Narsee Monjee College of Commerce and Economics, Mumbai in 1986 and thereafter enrolled at Somaya College, Mumbai for Management Studies.
While in college, he started participating in the theatre and thus began his acting career with Gujarati theatre from 1984. After having established himself as a sought-after theatre actor, he made his film debut with a brief role in the Aamir Khan and Manisha Koirala starred film Mann in 1999. He did several supporting and comic roles in films like No Entry, Delhi Belly, Rowdy Rathore and Freaky Ali to name a few. His performance in films like Welcome, Delhi Belly and Rowdy Rathore are among the most memorable roles, he has played thus far.
Apart from the silver screen, he is a well-known face in Indian television industry. He is acted in numerous television series like Comedy Nights with Kapil, Chidiya Ghar, Jasuben Jayantilaal Joshi Ki Joint Family and Ek Mahal Ho Sapno Ka to name a few.
In addition to performing on stage, movies and television series, he has done several commercials like Tata Phones, Symphony Air Coolers, LG TV, Coffee Bite, Dabur, Nerolac, and McDonald's.