His close friends from Thiruvananthapuram joined the film industry including the Singer M. G. Sreekumar, Megastar Mohanlal, and Producer Suresh Kumar to name a few. Priyadarshan came to industry by chance. He made his directorial debut with the Malayalam language film Poochakkoru Mookkuthi. This film was a huge hit and through this film, Priyadarshan got huge attention.
In his illustrious career, he has directed several hit films in Malayalam cinema during the 1980s and 1990s. He is considered as one of the directors who ushered charismatic cinematography and prolific background music to Malayalam films. In Bollywood, he is notable for making remakes of Malayalam films, which include hits like Gardish, Hera Pheri, Hulchul, "Kyunki" and Bhool Bhulaiyaa amongst others. His best work till date is arguably the Malayalam film Chithram, which released in 1988.
Priyadarshan started dating popular film Actress Lissy and they got married in 1990. The couple is blessed with a daughter Kalyani and a son Siddharth. The couple separated after 24 years of their marriage in 2014.