Screwvala began his professional career as a cable TV dealer in Mumbai. He produced content and advertisements for the famous Doordarshan serials like Shanti and Lifeline. Screwala established UTV group in 1990 which provided Television content to broadcasters. In less than 2 decades of its incorporation, UTV advanced into gaming, broadcasting, film producing and other businesses. The first film produced under the banner of UTV was Dil Ke Jharoke Main in 1997. UTV Motion Pictures then produced several hit films like Lakshya, Swades, Rang De Basanti, Life in a Metro, Jodhaa Akbar, Fashion and Barfi to name a few.
Apart from producing films his production company also started cartoon channel Hungama Tv and business channels like Bloomberg UTV. He resigned from UTV Group, a group formed and nurtured by him in 2014.
Ronnie Screwvala is a well-known entrepreneur and owns a Kabaddi team, U Muma. He also has stakes in e-commerce portals like zivame.com (well-known lingerie e-store) and lenskart.com (an eyewear shopping portal).
He has contributed immensely to the society through his NGO Swades Foundation. Swades has provided drinking water in 139 rural villages of Maharashtra.
He first married Suresh Nanavati’s (Chairman of prestigious Nanavati Hospitals in Mumbai) daughter, Manjula Nanavati. They have a daughter Trishya Screwvala. After divorcing his first wife Screwvala married Zarine Mehta.