Sadhna Sargams singing career has surpassed three decades now. Besides film music, she sings devotional songs, Classical music, ghazals, regional film songs and pop albums. She is a recipient of the National Film Award and Filmfare Awards South. She has won five Maharashtra State Film awards and four Gujarat State Film Awards.
Sargam was born to a family of musicians at Dabhol, the seaport town in Ratnagiri District of Maharashtra. Her mother Neela Ghanekar was a classical singer and music teacher and knew arranger–composer Anil Mohile, who was then arranging music for Kalyanji-Anandji. He introduced Sargam to them, and she was in the children’s chorus in "Pam Pararampam, Bole Jeevan Ki Sargam" sung by Kishore Kumar in G. P. Sippy’s Trishna in 1978.
Sargam made her playback debut in Kanku Pagli, a Gujarati film. Her first Hindi song was the solo "Door Nahin Rehna" from the film Rustom. However, Rustom was delayed and was released only in 1985, and Sargam ’s first released film was Subhash Ghai’s Vidhaata (1982) in which she sang the song "Saat Saheliyan" for actress Padmini Kolhapure.
In the early 1990s, Sargam emerged as one of the most sought-after female singers, along with Kavita Krishnamurthy, Alka Yagnik, and Anuradha Paudwal. She sang for composers like Anand–Milind, Nadeem–Shravan, Anu Malik, Jatin – Lalit, Bappi Lahiri, Viju Shah and Dilip Sen – Sameer Sen.
In 2011, Sargam made a contribution to the spiritual music world by singing an album: Mahalaxmi Mukti Samvad, MMS i.e. Mahalaxmi's Dialogues of Salvation.