Sanjay Suri started his career as a model after shifting to Delhi in 1990. He modeled for many companies including Gillette, Nilkamal Furniture, Times of India, Philishave, and Nescafe.
1999 witnessed Suri's breakthrough in Bollywood with a supporting role in the movie Pyaar Mein Kabhi Kabhi, co-starring Rinke Khanna, and Dino Morea. In 2003's Pinjar co-starring Urmila Matondkar he got rave reviews but it was not until Jhankaar Beats later that year that he became popular. His role alongside Juhi Chawla was greatly appreciated. Slowly he got more roles in movies, but his movies were not box office successes. Despite the failure of his films, his performances continued to be appreciated. In 2005 he delivered a critically acclaimed performance in My Brother... Nikhil, as a homosexual who happens to be HIV-positive, once again co-starring Juhi Chawla. The movie received unanimous praise among Indian film critics. The movie fared decently in Mumbai but was a failure elsewhere in India. His subsequent films have not done as well.
Suri later turned producer and as a producer, Suri and Onir under the banner of Anticlock Films have produced I Am which weaves together four stories on different topical issues. With this film, they have ventured into a new mode of production involving crowdsourcing, a concept that had not been explored before in Indian cinema. The film went on to win the National Film Award for Best Feature Film in Hindi in 2012.