Prior to becoming a professional wrestler, Santino was MMA fighter in Japan. In 2005 he moved to the United States and joined Ohio Valley Wrestling Federation to become an accomplished wrestler. Santino made his debut after signing a contract with World Wrestling Entertainment (WWE) on April 16, 2007. He is currently performing for RAW Brand. Santino is a former two times WWE Intercontinental Champion. Santino was among 28 participants in 2009 Royal Rumble but unfortunately, he was eliminated by Big Red Machine Kane within one second. Thus he breaks the elimination record of two seconds of “The Warlords “in 1989 Royal Rumble.
In 2014, after a third neck injury, Marella declared his retirement from professional wrestling.
Post retirement, Carrillo joined the Sportsnet One Aftermath panel as an analyst. Besides that, he has also started his acting career after retirement. He made his acting debut with the film Jingle All the Way 2 in 2014. To promote his film, he made an appearance at the WWE.
He was nicknamed as "Milan Miracle" and "The Italian Stallion" in the ring. His signature moves were Savate kick, Arm drag and Snap suplex among others.