He derived that he’s passionate about movies from a very early age. Throughout his school and college, he participated in several plays. He not only acted but also directed some plays. Keshavrao Date was left numb looking at the extraordinary talent that young Talwalkar possessed. He straightaway roped him for Natya Vikas Company.
Sharad Talwalkar made his acting debut with the film Akhar Zamla, which released in 1952. He along with Raja Gosavi played a comic role in the movie. The movie was successful and the duo of him and Raja Gosavi were instrumental in making this movie a huge hit. After this movie, the duo acted in many other projects. Along with movie he has been a prominent part of Marathi Theatre Industry. Gharo Ghari Heech Bomb, Ekach Pyala, and Lagnachi Bedi are some of his noteworthy plays.
On 22nd August 2001, he died off due to the heart attack at his residence in Pune.