Initially, Vanna had appeared in the first game show in the year 1980 and the episode name is – The Price Is Right. In this show, she was one of the four contestants. Later, in the year 1982, she got the opportunity to perform as the co-host in the show Wheel of Fortune. Consequently, she became the regular hostess of this show. Moreover, her autobiography titled as Vanna Speaks! was released in the year 1987 which was ultimately the best seller. In the same year, she was premiered in the Playboy pictorial wearing see-through lingerie. Consecutively, in the next year, she got an opportunity to perform in the role of Venus along with her co-artist Betsy Palmer in the television movie titled as Goddess of Love which was cast on NBC channel.
However, she has also made cameo appearances in many television shows which mainly includes L.A. Law, Super Mario Bros, Simon and Simon, Full House, 227, Super Show, The King of Queens, and much more along with the movie named as Naked Gun – The Final Insult. She has also appeared in the low-budget movie named as Graduation Day in the year 1981. In the year 2006, she was respected with a star on the Hollywood Walk of Fame along with Merv Griffin, Pat Sajak, and Alex Trebek who served as the key witnesses.