Duque relocated to Miami with her mother after her parents divorced. She finished her schooling in Miami and subsequently auditioned for the second season of a reality Television show, Protagonistas de Novela, in which sixteen participants compete to grab a contract to appear in a Telemundo-directed telenovela. She shot to fame after featuring on the show. Though she lost the competition but got enough notices and after which she has gone on to appear in many telenovelas, including El Rostro de Analia, Pecados Ajenos, Los Victorinos, Valeria, Corazón Valiente, La Casa de al Lado, and Santa Diabla
She was romantically involved with her co-actor Fabián Ríos. They won the Perfect Couple and Hottest Kiss As A Couple award in Premios Tu Mundo, Their fans are eagerly waiting to watch the couple on another telenovela together. Her latest appearance was in Santa Diabla in 2013.
Apart from acting in Telenovelas, she has also acted in films. She made her film debut with the film Primero de Enero in 2014.